Hypertension in peri- and postmenopausal women — pathophysiological mechanisms and approaches to treatment

This review presents epidemiological data on the effect of sex hormones and reproductive status level blood pressure (BP) incidence es­sential hypertension (EHT) in women. The role estrogen deprivation hyper­androgenism development EHT peri- postmenopause is discussed. main mechanisms periand postmenopausal women: sympathetic renin-angiotensin-aldosterone system hyperactivity, salt-sensitivity, high prevalence abdominal obesity, metabolic syndrome, left ventricular hypertrophy, atrial dilatation risk fibrillation, stroke heart failure with preserved ventricle ejection fraction. Data efficacy tolerability classes antihypertensive drugs women presented. We discussed selective I1-imidazoline receptor agonists results cohort studies moxonidine monotherapy its combination other hormonal menopausal therapy post­menopausal Moxonidine reduces has a beneficial syndrome components, but also effective patients hypertensive crises, especially hyperactivity.